Lots of interesting opinions in this thread! It just made me go back to Ernie Ball 9s now and I will try the Gibson Brite Wire 9s soon. When I started playing guitar I quickly moved from EB Super Slinky (9-42) to Hybrid Slinky (9-46) and then to Regular Slinky (10-46). I found it easier to play the slightly thicker high strings as it does require less precision and sensitivity compared to 9s. I also thought thicker strings might help to strenghten my hand muscles. But now I actually came to the conclusion that light touch and sensitivity is very desirable so I am very happy with 9-42 now (at least in standard tuning).